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Board Review: IgG Subclass Deficiency
1.
Which of the following antibody concentrations must be normal for the patient to qualify for the diagnosis of IgG Subclass Deficiency?
IgA
IgM
IgG
IgE
None
2.
Which IgG subclass accounts for the majority of the total IgG concentration?
IgG 1
IgG 2
IgG 3
IgG 4
None
3.
The IgG subclass primarily responsible for the antibody response to polysaccharide capsular antigens is ___ ?
IgG 1
IgG 2
IgG 3
IgG 4
None
4.
A 39 y/o woman presents for ID evaluation. She has a history of recurrent herpes simplex meningitis and bronchospastic illness. The most likely IgG subclass deficiency responsible for this clinical presentation is:
IgG 1
IgG 2
IgG 3
IgG 4
None
5.
A patient presents with an isolated IgG 1 deficiency. Which of the following is also likely to be true?
IgA and/or IgM is also low
Response to pneumococcal polysaccharide vaccine is likely to be normal
Bronchospastic illness is common
Intravenous immune globulin is ineffective
None
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